The Andrew Hanson Lab

Bryan J Leong, Jacob S Folz, Ulschan Bathe, David G Clark, Oliver Fiehn, Andrew D Hanson (2022). Fluoroacetate distribution, response to fluoridation, and synthesis in juvenile Gastrolobium bilobum plants

Drago Haas, Antje M Thamm, Jiayi Sun, Lili Huang, Lijie Sun, Guillaume AW Beaudoin, Kim S Wise, Claudia Lerma-Ortiz, Steven D Bruner, Marian Breuer, Zaida Luthey-Schulten, Jiusheng Lin, Mark A Wilson, Greg Brown, Alexander F Yakunin, Inna Kurilyak, Jacob Folz, Oliver Fiehn, John I Glass, Andrew D Hanson, Christopher S Henry, Valérie de Crécy-Lagard (2022). Metabolite Damage and Damage Control in a Minimal Genome

Rosana S Molina, Gordon Rix, Amanuella A Mengiste, Beatriz Álvarez, Daeje Seo, Haiqi Chen, Juan E Hurtado, Qiong Zhang, Jorge Donato García-García, Zachary J Heins, Patrick J Almhjell, Frances H Arnold, Ahmad S Khalil, Andrew D Hanson, John E Dueber, David V Schaffer, Fei Chen, Seokhee Kim, Luis Ángel Fernández, Matthew D Shoulders, Chang C Liu (2022). In vivo hypermutation and continuous evolution

Jorge D García-García, Kristen Van Gelder, Jaya Joshi, Ulschan Bathe, Bryan J Leong, Steven D Bruner, Chang C Liu, Andrew D Hanson (2022). Using continuous directed evolution to improve enzymes for plant applications

James G Jeffryes, Claudia Lerma-Ortiz, Filipe Liu, Alexey Golubev, Thomas D Niehaus, Mona Elbadawi-Sidhu, Oliver Fiehn, Andrew D Hanson, Keith EJ Tyo, Christopher S Henry (2022). Chemical-damage MINE: A database of curated and predicted spontaneous metabolic reactions

Jaya Joshi, Ghulam Hasnain, Taylor Logue, Madeline Lynch, Shan Wu, Jiahn-Chou Guan, Saleh Alseekh, Alisdair R Fernie, Andrew D Hanson, Donald R McCarty (2021). A core metabolome response of maize leaves subjected to long-duration abiotic stresses

Ulschan Bathe, Bryan J Leong, Donald R McCarty, Christopher S Henry, Paul E Abraham, Mark A Wilson, Andrew D Hanson (2021). The Moderately (D)efficient Enzyme: Catalysis-Related Damage In Vivo and Its Repair

Jaya Joshi, Qiang Li, Jorge D García-García, Bryan J Leong, You Hu, Steven D Bruner, Andrew D Hanson (2021). Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Andrew D Hanson, Donald R McCarty, Christopher S Henry, Xiaochen Xian, Jaya Joshi, Jenelle A Patterson, Jorge D García-García, Scott D Fleischmann, Nathan D Tivendale, A Harvey Millar (2021). The number of catalytic cycles in an enzyme’s lifetime and why it matters to metabolic engineering

Jacob S Folz, Jenelle A Patterson, Andrew D Hanson, Oliver Fiehn (2021). Quantification of N6-formylated lysine in bacterial protein digests using liquid chromatography/tandem mass spectrometry despite spontaneous formation and matrix effects

Jaya Joshi, Manaki Mimura, Masaharu Suzuki, Shan Wu, Jesse F Gregory III, Andrew D Hanson, Donald R McCarty (2021). The Thiamin-Requiring 3 Mutation of Arabidopsis 5-Deoxyxylulose-Phosphate Synthase 1 Highlights How the Thiamin Economy Impacts the Methylerythritol 4-Phosphate Pathway

Taylor Kornfuehrer, Sean Romanowski, Valérie de Crécy‐Lagard, Andrew D Hanson, Alessandra S Eustáquio (2020). An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (Rs,Sc)‐S‐Adenosylmethionine Hydrolase

Jorge D García-García, Jaya Joshi, Jenelle A Patterson, Lidimarie Trujillo-Rodriguez, Christopher R Reisch, Alex A Javanpour, Chang C Liu, Andrew D Hanson (2020). Potential for Applying Continuous Directed Evolution to Plant Enzymes: An Exploratory Study

Jaya Joshi, Guillaume AW Beaudoin, Jenelle A Patterson, Jorge D García-García, Catherine E Belisle, Lan-Yen Chang, Lei Li, Owen Duncan, A Harvey Millar, Andrew D (2020) Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s

Jenelle A Patterson, Hai He, Jacob S Folz, Qiang Li, Mark A Wilson, Oliver Fiehn, Steven D Bruner, Arren Bar-Even, Andrew D Hanson (2020) Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli

Hai He, Elad Noor, Perla A Ramos-Parra, Liliana E García-Valencia, Jenelle A Patterson, Rocío I Díaz de la Garza, Andrew D Hanson, Arren Bar-Even (2020) In Vivo Rate of Formaldehyde Condensation with Tetrahydrofolate

Suzuki M, Wu S, Mimura M, Alseekh S, Fernie AR, Hanson AD, McCarty DR (2019). Construction and applications of a B vitamin genetic resource for investigation of vitamin dependent metabolism in maize.

de Crécy-Lagard V, Haas D, Hanson AD (2018). Newly-discovered enzymes that function in metabolite damage-control.

Joshi J, Folz J, Gregory JF, McCarty DR, Fiehn O, Hanson AD (2019). Rethinking the PDH Bypass and GABA Shunt as Thiamin-Deficiency Workarounds.

Niehaus TD, Patterson JA, Alexander DC, Folz JS, Pyc M, MacTavish BS, Bruner SD, Mullen RT, Fiehn O, Hanson AD (2019). The metabolite repair enzyme Nit1 is a dual-targeted amidase that disposes of damaged glutathione in Arabidopsis.

Sun J, Sigler CL, Beaudoin GA, Joshi J, Patterson JA, Cho KH, Ralat MA, Gregory JF, Clark DG,Deng Z, Colquhoun, TA and Hanson, AD (2019). Parts-prospecting for a high-efficiency thiamin thiazole biosynthesis pathway.

Amthor JS, Bar-Even A, Hanson AD, Millar AH, Stitt M, Sweetlove LJ, Tyerman SD (2019). Engineering Strategies to Boost Crop Productivity by Cutting Respiratory Carbon Loss.

Beaudoin GAW, Li Q, Folz J, Fiehn O, Goodsell JL, Angerhofer A, Bruner SD, Hanson AD. Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.

Tian X, Werner ME, Roche KC, Hanson AD, Foote HP, Yu SK, Warner SB, Copp JA, Lara H, Wauthier EL, Caster JM, Herring LE, Zhang L, Tepper JE, Hsu DS, Zhang T, Reid LM, Wang AZ (2018). Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.

Stewart CN Jr, Patron N, Hanson AD, Jez JM (2018). Plant metabolic engineering in the synthetic biology era: plant chassis selection.

Sane S, Hafner A, Srinivasan R, Masood D, Slunecka JL, Noldner CJ, Hanson AD, Kruisselbrink T, Wang X, Wang Y, Yin J, Rezvani K (2018). UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells.

Hanson AD, Amthor JS, Sun J, Niehaus TD, Gregory JF 3rd, Bruner SD, Ding Y. Redesigning thiamin synthesis: Prospects and potential payoffs.

Seaver SMD, Lerma-Ortiz C, Conrad N, Mikaili A, Sreedasyam A, Hanson AD, Henry CS. PlantSEED enables automated annotation and reconstruction of plant primary metabolism with improved compartmentalization and comparative consistency.

Niehaus TD, Folz J, McCarty DR, Cooper AJL, Moraga Amador D, Fiehn O, Hanson AD. Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis.

Paerl RW, Bertrand EM, Rowland E, Schatt P, Mehiri M, Niehaus TD, Hanson AD, Riemann L, Bouget FY. Carboxythiazole is a key microbial nutrient currency and critical component of thiamin biosynthesis.

Niehaus TD, Elbadawi-Sidhu M, Huang L, Prunetti L, Gregory JF 3rd, de Crécy-Lagard V, Fiehn O, Hanson AD. Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

Sun J, Jeffryes JG, Henry CS, Bruner SD, Hanson AD (2017. Metabolite damage and repair in metabolic engineering design.

Beaudoin GA, Li Q, Bruner SD, Hanson AD (2017). An unusual diphosphatase from the PhnP family cleaves reactive FAD photoproducts.

Golubev A, Hanson AD, Gladyshev VN (2017). A tale of two concepts: Harmonizing the free radical and antagonistic pleiotropy theories of aging.

Hanson AD Beaudoin GA, McCarty DR, Gregory JF 3rd (2016). Does abiotic stress cause functional B vitamin deficiency in plants?

Niehaus TD, Elbadawi-Sidhu M, de Crécy-Lagard V, Fiehn O, Hanson AD (2017). Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight.

Thamm AM, Li G, Taja-Moreno M, Gerdes SY, de Crécy-Lagard V, Bruner SD, Hanson AD (2017). A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis.

Golubev A, Hanson AD, Gladyshev VN (2017. Non-enzymatic molecular damage as a prototypic driver of aging.

Frelin O, Dervinis C, Wegrzyn JL, Davis JM, Hanson AD (2017). Drought stress in Pinus taeda L. induces coordinated transcript accumulation of genes involved in the homogentisate pathway.

Jaya Joshi, Guillaume AW Beaudoin, Jenelle A Patterson, Jorge D García-García, Catherine E Belisle, Lan-Yen Chang, Lei Li, Owen Duncan, A Harvey Millar, Andrew D Hanson (2020). Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s

Mimura M, Zallot R, Niehaus TD, Hasnain G, Gidda SK, Nguyen TN, Anderson EM, Mullen RT, Brown G, Yakunin AF, de Crécy-Lagard V, Gregory JF 3rd, McCarty DR, Hanson AD (2016). Arabidopsis TH2 encodes the orphan enzyme thiamin monophosphate phosphatase.

Henry CS, Lerma-Ortiz C, Gerdes SY, Mullen JD, Colasanti R, Zhukov A, Frelin O, Thiaville JJ, Zallot R, Niehaus TD, Hasnain G, Conrad N, Hanson AD, de Crécy-Lagard V (2016). Systematic identification and analysis of frequent gene fusion events in metabolic pathways.

Huang L, Khusnutdinova A, Nocek B, Brown G, Xu X, Cui H, Petit P, Flick R, Zallot R, Balmant K, Ziemak MJ, Shanklin J, de Crécy-Lagard V, Fiehn O, Gregory JF 3rd, Joachimiak A, Savchenko A, Yakunin AF, Hanson AD (2016). A family of metal-dependent phosphatases implicated in metabolite damage-control.